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Click here to read online | | |      | | Tuesday, January 31, 2012. In the journal BMC Medicine on January 26, 2012, Professor Sanjay K. Srivastava and Prabodh K. Kandala of Texas Tech University Health Sciences Center in Amarillo report the discovery of a mechanism for diindolylmethane (DIM), an active metabolite of indole-3-carbinol found in cruciferous vegetables, to induce programmed cell death (apoptosis) in cultured ovarian cancer cells. Previous research uncovered an inhibitory effect for DIM on ovarian cancer cell growth, yet the mechanism involved remained unknown. The current study explored the effects of DIM in several ovarian cancer lines. Drs Srivastava and Kandala found that DIM induces apoptosis, and that it exerts its effects by blocking the production and activation of signal transducer and activator of transcription(STAT3), a transcription factor that is associated with the growth and survival of cells which is over-expressed in cases of resistance to the chemotherapy cisplatin. DIM also reduced the proinflammatory cytokine interleukin-in ovarian tumor cells, and inhibited cell invasion and angiogenesis via suppression of hypoxia-inducible factor 1-alpha and vascular epithelial growth factor. 
|  |  |  | | An article published online on October 17, 2011 in the Journal of Clinical Investigation revealed that sulforaphane, a compound that occurs in broccoli and other cruciferous vegetables, improves sensitivity to corticosteroid drugs used to treat chronic obstructive pulmonary disease (COPD), a condition that is mainly the result of smoking, characterized by chronic bronchitis and emphysema. The disease is currently treated with corticosteroids, however, the drugs only reduce symptoms by approximatelypercent. Individuals diagnosed with COPD experience a reduction in their lungs of histone deacetylase(HDAC2), a substance that is essential to the anti-inflammatory pathway initiated by steroid drugs. In the current research, a team from Johns Hopkins University discovered that S-nitrosylation of HCAC2 due to cigarette smoke exposure resulted in HDAC2 dysfunction in lung macrophages derived from individuals with COPD. "This study provides the mechanism of exaggerated inflammation observed in COPD patients during exacerbations, which has been a barrier to developing effective therapy," stated coauthor Rajesh Thimmulappa, PhD, who is an assistant scientist at Johns Hopkins Bloomberg School of Medicine's Department of Environmental Health Sciences. It was further discovered that sulforaphane denitrosylates HDAC2, which restored corticosteroid sensitivity. In previous research, the team demonstrated that sulforaphane activates a pathway known as Nrf2. "Restoring corticosteroid sensitivity in patients with COPD by targeting the Nrf2 pathway holds promise for effectively treating exacerbations," noted senior author Shyam Biswal, PhD, who is a professor at the Bloomberg School of Medicine's Department of Environmental Health Sciences and Division of Pulmonary and Critical Care Medicine. "Nrf2 activators such as sulforaphane can counteract oxidative and nitrosative stress and mediate glutathione-dependent denitrosylation, thereby restoring HDAC2 activity," the authors write. "The small-molecule Nrf2 activator sulforaphane may be useful as an adjuvant therapy to augment the antiinflammatory effects of glucocorticosteroids in COPD and other inflammatory diseases." | 
Don't miss this opportunity to stock up on all your favorites or try something new at the lowest prices you'll find this season. There's no better time to save than Super Sale. So call toll-free 1-800-544-4440 to order now! But hurry. This sale ends January 31, 2012 *Price based on 4-bottle Super Sale member purchase.
**Price based on 6-pouch Super Sale member purchase.
http://www.lef.org/SuperSale/ | |  | 
|  | | Hunger is the factor that often precludes most people from even considering a low-calorie diet. Pinolenic acid, from the Korean Pine Nut, stimulates the release of two of the body's most powerful hunger-suppressing hormones: CCK (cholecystokinin) and GLP-(glucagon-like peptide-1). This sends a feeling of satiety or fullness to the brain, decreasing the desire to eat and helping to control excessive calorie intake. People taking this oil had an increase in the satiety hormones CCK and GLP-in the bloodstream and a 36% reduced desire to eat. | |  | | Omega-Chewables feature a state-of-the-art micro-encapsulation technology. This "double-shell" protection system keeps the fish oil locked into tiny capsules contained in each soft chew. They intact into your gastrointestinal tract, where they're broken down and absorbed. No fishy taste, no aftertaste. Each Omega-Chewable supplies 120 mg of EPA and DHA fatty acids. It's a nice way to help children (and some adults) increase their omega-intake. Most adults will | | |  | 
| AprèsFlex is a trademark of Laila Nutraceuticals exclusively licensed to PL Thomas – Laila Nutra LLC. International patents pending. | |   
*These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure, or prevent any disease. | | If you have questions or comments concerning this issue or past issues of Life Extension Update, them Life Extension reserves the right to make adjustments in its sole discretion to any price, product or offer contained in thisdue to market conditions, product discontinuations, manufacturer price changes, errors in advertisements, product descriptions or any other circumstance. Additionally, Life Extension reserves the right to limit quantities on any items advertised in this All orders are subject to approval by Life Extension. Life Extension will not be liable for any errors, typographical or photographic or otherwise, for product information, pricing or other content, that may appear in thisor any other electronic or print communication that contains offers to purchase products or services from Life Extension Foundation Buyers Club, Inc. or any of its affiliates. All Contents Copyright 1995-2012 Life Extension All Rights Reserved. LifeExtension.com, Inc.3600 W. Commercial Blvd.Fort Lauderdale FL 33309 | 
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Life Extension
Mechanism found for DIM in reducing ovarian cancer cell growth
Tuesday, January 31, 2012. In the journal BMC Medicine on January 26, 2012, Professor Sanjay K. Srivastava and Prabodh K. Kandala of Texas Tech University Health Sciences Center in Amarillo report the discovery of a mechanism for diindolylmethane (DIM), an active metabolite of indole-3-carbinol found in cruciferous vegetables, to induce programmed cell death (apoptosis) in cultured ovarian cancer cells.
Previous research uncovered an inhibitory effect for DIM on ovarian cancer cell growth, yet the mechanism involved remained unknown. The current study explored the effects of DIM in several ovarian cancer lines. Drs Srivastava and Kandala found that DIM induces apoptosis, and that it exerts its effects by blocking the production and activation of signal transducer and activator of transcription(STAT3), a transcription factor that is associated with the growth and survival of cells which is over-expressed in cases of resistance to the chemotherapy cisplatin. DIM also reduced the proinflammatory cytokine interleukin-in ovarian tumor cells, and inhibited cell invasion and angiogenesis via suppression of hypoxia-inducible factor 1-alpha and vascular epithelial growth factor.
In further experimentation, the duo pretreated ovarian cancer cells with DIM, followed by the administration of cisplatin forhours. The combination of DIM and cisplatin resulted in atopercent reduction in cell survival, in contrast with apercent reduction in cells treated with cisplatin alone. Furthermore, mice treated with DIM alone or DIM and cisplatin experienced retarded growth of implanted ovarian tumors compared to untreated mice or animals that received cisplatin alone. "Our results demonstrate that DIM suppresses the growth of ovarian cancer cells and potentiates the effect of cisplatin in vitro and in vivo by targeting STAT3 signaling without being toxic to normal ovarian cells," the authors write. "To the best of our knowledge, this is the first report demonstrating STAT3 as a target of DIM."
"Cisplatin is very toxic and has severe side effects," Drs Srivastava and Kandala explained. "If co-treatment with DIM means that a low dose of cisplatin can be given to patients without the loss of therapeutic effect, but with reduced side effects, it would represent a significant breakthrough in clinical practice."
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What's Hot
Broccoli compound improves steroid response in COPD patients
An article published online on October 17, 2011 in the Journal of Clinical Investigation revealed that sulforaphane, a compound that occurs in broccoli and other cruciferous vegetables, improves sensitivity to corticosteroid drugs used to treat chronic obstructive pulmonary disease (COPD), a condition that is mainly the result of smoking, characterized by chronic bronchitis and emphysema. The disease is currently treated with corticosteroids, however, the drugs only reduce symptoms by approximatelypercent.
Individuals diagnosed with COPD experience a reduction in their lungs of histone deacetylase(HDAC2), a substance that is essential to the anti-inflammatory pathway initiated by steroid drugs. In the current research, a team from Johns Hopkins University discovered that S-nitrosylation of HCAC2 due to cigarette smoke exposure resulted in HDAC2 dysfunction in lung macrophages derived from individuals with COPD. "This study provides the mechanism of exaggerated inflammation observed in COPD patients during exacerbations, which has been a barrier to developing effective therapy," stated coauthor Rajesh Thimmulappa, PhD, who is an assistant scientist at Johns Hopkins Bloomberg School of Medicine's Department of Environmental Health Sciences.
It was further discovered that sulforaphane denitrosylates HDAC2, which restored corticosteroid sensitivity. In previous research, the team demonstrated that sulforaphane activates a pathway known as Nrf2. "Restoring corticosteroid sensitivity in patients with COPD by targeting the Nrf2 pathway holds promise for effectively treating exacerbations," noted senior author Shyam Biswal, PhD, who is a professor at the Bloomberg School of Medicine's Department of Environmental Health Sciences and Division of Pulmonary and Critical Care Medicine.
"Nrf2 activators such as sulforaphane can counteract oxidative and nitrosative stress and mediate glutathione-dependent denitrosylation, thereby restoring HDAC2 activity," the authors write. "The small-molecule Nrf2 activator sulforaphane may be useful as an adjuvant therapy to augment the antiinflammatory effects of glucocorticosteroids in COPD and other inflammatory diseases."
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Life Extension Highlight
Don't Miss Out on This Year's Super Sale Savings!
Don't miss this opportunity to stock up on all your favorites or try something new at the lowest prices you'll find this season. There's no better time to save than Super Sale. So call toll-free 1-800-544-4440 to order now! But hurry. This sale ends January 31, 2012.
Two-Per-Day 120 vegetarian tablets
Item #01615
$ $15*
Cruciferous Vegetable Soupounces
Item #01519
$ $59**
5-LOX Inhibitor with Apr?s-Flex?vegetarian capsules
Item #01639
$ $50*
Mega Green Tea with CoffeeGenic? Green Coffee Extract (low caffeine formula) 120 vegetarian capsules
Item #01606
$ $90*
Ultra Natural Prostate with Apr?s-Flex? and Standardized Lignanssoftgels
Item #01695
$ $63*
Neuro-Mag? Magnesium L-Threonate with Calcium and Vitamin D3 205 grams
Item #01602
$ $30*
*Price based on 4-bottle Super Sale member purchase.
**Price based on 6-pouch Super Sale member purchase.
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Natural Appetite Control
Item #00891
Hunger is the factor that often precludes most people from even considering a low-calorie diet. Pinolenic acid, from the Korean Pine Nut, stimulates the release of two of the body's most powerful hunger-suppressing hormones: CCK (cholecystokinin) and GLP-(glucagon-like peptide-1). This sends a feeling of satiety or fullness to the brain, decreasing the desire to eat and helping to control excessive calorie intake. People taking this oil had an increase in the satiety hormones CCK and GLP-in the bloodstream and a 36% reduced desire to eat.
Omega-Chewables
Item #01518
Omega-Chewables feature a state-of-the-art micro-encapsulation technology. This "double-shell" protection system keeps the fish oil locked into tiny capsules contained in each soft chew. They intact into your gastrointestinal tract, where they're broken down and absorbed. No fishy taste, no aftertaste.
Each Omega-Chewable supplies 120 mg of EPA and DHA fatty acids. It's a nice way to help children (and some adults) increase their omega-intake. Most adults will
News Archive
Life Extension
New research contributes to the understanding of how I3C blocks cancer cells
Just one cup of green tea per day cuts ovarian cancer risk in half
Another cancer linked with reduced vitamin D levels
- What's Hot
Resveratrol suppresses ovarian cancer growth in laboratory studies
Broccoli, red chili compounds inhibit cancer cell growth
High dietary folate associated with lower ovarian cancer risk
- Life Extension? Magazine
Powerful advances in natural cancer prevention
I3C & DIM: natural, dual-action protection against deadly cancers
I3C vs DIM
- Health Topics
Cancer adjuvant therapy
Complementary alternative cancer therapies
Cancer treatment: the critical factors
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These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
Life Extension Update January 31, 2012
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